Children living in disadvantaged neighborhoods are more likely to become obese and have mental disorders than those growing up in more advantageous areas. This effect seems to depend more on the environment and not so much on a child’s genetic risk, a study suggests. The reasons…
A home environment that promotes obesity, such as eating unhealthy food, doing less exercise, and having more sedentary behaviors, makes children at risk for genetic obesity more vulnerable to excessive weight gain, according to a study. This susceptibility was significantly lower in…
Genetic obesity increases the production of proteins involved in freeing pancreatic cells from excess cholesterol, which may help protect their ability to produce insulin, an early study in rats suggests. The mechanism may also explain why some people with a pre-diabetic precursor condition are able to…
Setmelanotide is showing promising efficacy to reduce weight and hunger in patients with melanocortin-4 receptor (MC4R) pathway heterozygous obesity, particularly those with more severe genetic mutations, announced the treatment’s developer Rhythm Pharmaceuticals. The findings come…
Rhythm Pharmaceuticals expects the first results of Phase 3 trials assessing its lead candidate setmelanotide for POMC and LEPR deficiency obesity in the third quarter of 2019. The company also plans to apply for a new drug application…
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