Treatment with setmelanotide continues to provide significant weight loss at two years in six of nine patients with Bardet-Biedl syndrome (BBS) taking part in an ongoing Phase 2/3 basket trial. Also, five patients have experienced a significant decrease in hunger. These findings support previously reported results by…
Children who are breastfed have a lower risk of obesity, which might be because of fewer specific genetic changes in the LEP gene — the gene coding for the leptin hormone, which controls appetite and energy expenditure, according to a new study. The research, “Leptin Gene Methylation…
The genetic susceptibility to increased insulin sensitivity that leads to the accumulation of fat in the hip rather than waist also reduces the risk of cardiometabolic disease — diabetes, heart disease, or stroke — in children and adolescents, according to a large study in Europe. The research, “…
A high genetic risk for obesity in Hispanic mothers is associated with increased fetal weight throughout pregnancy, according to new research in the U.S. The data also showed that, depending on the sex of the offspring, this risk had a different effect on fetal and birth weights in Black and…
People born in the U.S. have higher body mass index (BMI) and a greater risk of obesity than those born abroad, according to a large New York-based study. The data also revealed that African ancestry is associated with the likelihood of being obese in U.S.-born women. The research, “…
A specific variant of the LRP1B gene, and other alterations that affect protein production from this gene, are associated with severe obesity in children, according to a new study. The research, “The genetic and epigenetic association of LDL Receptor Related Protein 1B (LRP1B) gene with childhood…
A specific variant of the LEPR gene is associated with obesity, according to a study in Chinese adolescents of Han ethnicity. The research, “Association study between LEPR, MC4R polymorphisms and overweight/obesity in Chinese Han adolescents,” was published in the journal Gene. According to previous studies,…
Loss of a protein called Tbx3 leads to glucose intolerance and obesity, with associated changes in the identity of key groups of neurons implicated in appetite, according to new research in animal models and in human cells. The study, “Functional identity of hypothalamic melanocortin neurons depends on…
A report describes the rare case of a woman with Bardet-Biedl syndrome (BBS), endometrial cancer, signs of excess estrogen, and who underwent removal of her uterus and fallopian tubes. The case report, “Endometrial Carcinoma in a 26-Year-Old Patient with Bardet-Biedl Syndrome,” was published in the journal…
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