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Genetic Risk for Obesity Linked to Shorter Lifespan, Study Reports

Having a greater genetic likelihood for high blood pressure and obesity may correlate with a shorter lifespan, a large international study reports. This type of analysis could help identify those most likely to benefit from medical or lifestyle interventions, according to the scientists. The study, “Trans-biobank analysis…

New Model Can Estimate Gene-Environment Effects on Obesity Traits, Study Says

Researchers have developed a statistical model to better estimate how the interaction between genetic and environmental factors can affect obesity risk, potentially helping public health authorities to focus on specific environmental factors to mitigate this risk. The study, “Quantification of the overall contribution of gene-environment interaction for obesity-related traits,”…

NORD’s Advice on COVID-19: You’re Stronger Than You Think

First, the bad news: If you’re one of the 30 million or so Americans with a rare disease, you probably have lower immunity to the novel coronavirus than most people. Now, the good news: You already know how to face loneliness and adversity — qualities that make you far stronger…

Rhythm Seeks FDA Approval of Setmelanotide for POMC/LEPR Deficiency

Rhythm Pharmaceuticals is seeking approval from the U.S. Food and Drug Administration (FDA) for its lead candidate setmelanotide to treat POMC deficiency and LEPR deficiency, two rare genetic obesity disorders. Over the next two months, the FDA will determine whether Rhythm’s new drug application (NDA) is acceptable for filing…

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