Genetics doesn’t just influence a person’s weight, but also how that weight changes in response to weight-loss interventions, a recent study found. Titled, “Genetic predictors of weight loss in overweight and obese subjects,” the study was published in Scientific Reports. When a person’s weight becomes a medical…
Exercises such as regular jogging, mountain climbing, and walking can reduce the effects of genetic predisposition to obesity, new research suggests. However, the genetic effects on obesity do not seem to be influenced by other exercises, such as cycling, stretching, or swimming. The data were published in the journal PLOS…
The genetic susceptibility to increased insulin sensitivity that leads to the accumulation of fat in the hip rather than waist also reduces the risk of cardiometabolic disease — diabetes, heart disease, or stroke — in children and adolescents, according to a large study in Europe. The research, “…
Imagine living your whole life with a painful disease so rare that only 25 others worldwide have what you have. And that you’re one of just six such people who’ve made it to adulthood. Neena Nizar doesn’t have to imagine. The 41-year-old English professor at Metro Community College in Elkhorn,…
Two ongoing Phase 3 clinical trials assessing the effects of setmelanotide as an obesity treatment for patients with proopiomelanocortin (POMC) and leptin receptor (LEPR) deficiency have met their primary goals, Rhythm Pharmaceuticals announced. A high proportion of patients in both studies achieved more…
Rhythm Pharmaceuticals is expected to announce top-line results from its ongoing Phase 3 trials exploring setmelanotide as an obesity treatment for patients with POMC and LEPR deficiency during the third quarter of 2019. The trials (NCT02896192 and NCT03287960) are still recruiting participants in the United…
Eating more fruits and vegetables can lead to less weight gain, and this effect is strongest among those who are genetically predisposed to be obese, a new study has found. The study, titled “Improving fruit and vegetable intake attenuates the genetic association with long-term weight gain,” was…
Oklahoma suffers more tornadoes than any other state, has the highest per-capita rate of women in U.S. prisons, ranks second in the number of teen births per 100,000 teenage girls, and has the nation’s third-highest rate of uninsured residents — with 13.9% of all Oklahomans lacking health coverage. As if…
Screening newborns for genetic diseases with treatments that can prevent crippling or deadly progression, especially for rare disorders, has a ways to go in the United States. No state today tests for all 35 disorders recommended under a federal screening panel, and even in those that come close, rare…
A branch of the European Medicines Agency (EMA) has recommended that Rhythm‘s setmelanotide be designated an orphan medicine to treat people with Bardet-Biedl syndrome (BBS), a rare genetic disorder of obesity. The positive opinion of EMA’s Committee for Orphan Medicinal Products (COMP) puts setmelanotide closer to…
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